Recent Faculty Publications: "Angiotensin I Infusion Reveals Differential Effects of Angiotensin-Converting Enzyme in Aortic Resident Cells on Aneurysm Formation."
- 1
- Saha Cardiovascular Research Center, University of Kentucky.
- 2
- Department of Physiology, University of Kentucky.
Abstract
BACKGROUND:
Angiotensin (Ang)I is cleaved by angiotensin-converting enzyme (ACE) to generate AngII. The purpose of this study was to determine the roles of ACE in endothelial and smooth muscle cells in aortic aneurysms.Methods鈥刟nd鈥凴esults:AngI infusion led to thoracic and abdominal aortic aneurysms in low-density lipoprotein receptor-deficient mice, which were ablated by ACE inhibition. Endothelial or smooth muscle cell-specific ACE deletion resulted in reduction of AngI-induced thoracic, but not abdominal, aortic dilatation.
CONCLUSIONS:
AngI infusion causes thoracic and abdominal aortic aneurysms in mice. ACE in aortic resident cells has differential effects on AngI-induced thoracic and abdominal aortic aneurysms.
KEYWORDS:
Angiotensin; Angiotensin-converting enzyme; Aortic aneurysm; Endothelial cells; Smooth muscle cells
- PMID:
- 32238693
- DOI:
